
| Therapy | Approach | Indications | Contraindications | Advantages | Disadvantages |
| Cognitive Behavioral Therapy | Integrates cognitive and behavioral techniques to modify dysfunctional patterns. | Mild to moderate depression; effective as monotherapy or combined with medication. | Low motivation or marked cognitive impairment. | Structured, standardized, problem-focused. | Requires active commitment and continuity. |
| Behavior Therapy | Stimulates rewarding behaviors and environmental interaction. | Anhedonia, apathy, social withdrawal; useful in combination or as an initial step. | Intrusive depressive thoughts or marked suicidal ideation. | Simple to apply; useful for early reactivation. | Does not address deep cognitive content. |
| Cognitive Therapy | Restructures negative automatic thoughts and dysfunctional beliefs. | Prominent cognitive distortions; used in monotherapy or combination. | Difficulties with introspection or abstract thinking. | Targeted and based on validated models. | Less effective with passive or unreflective patients. |
| Interpersonal Therapy | Focuses on loss, conflict, and relational transitions. | Postpartum, grief-related, or relational depression; effective as monotherapy or with medication. | Poor emotional insight or severe isolation. | Time-limited, focused, relational. | Requires emotional awareness and introspection. |
| Brief Psychodynamic Therapy | Explores unconscious conflicts and early relational dynamics. | Reactive or situational depression; used in combination with pharmacotherapy. | Disorganized functioning or concrete thinking. | Promotes emotional processing and identity continuity. | Slower response; requires consistency and reflection. |
| Problem-Solving Therapy | Teaches adaptive strategies to manage practical and stressful problems. | Reactive depression; effective as monotherapy or in primary care settings. | Severe anergia or major decisional blocks. | Brief, pragmatic, easy to implement. | Limited impact on deep or recurrent affective disorders. |
| Metacognitive Therapy | Targets rumination, hypervigilance, and excessive mental control. | Persistent rumination or comorbid anxiety; effective alone or in combination. | Cognitive rigidity or poor metacognitive awareness. | Focused on transdiagnostic mechanisms. | Requires abstraction and active collaboration. |
| Acceptance and Commitment Therapy | Promotes acceptance of inner experiences and value-driven actions. | Chronic or resistant depression, somatic or avoidant features; used alone or in combination. | Low emotional tolerance, resistance to awareness. | Enhances psychological flexibility and value-based motivation. | Can be abstract or frustrating for certain patients. |
| Mindfulness-Based Cognitive Therapy | Combines meditation and non-judgmental awareness to prevent relapse. | Maintenance or partial remission phase; used in combination with CBT or medication. | Acute depression, psychosis, dissociation. | Improves attentional control and relapse prevention. | Less effective in acute phases; requires consistent practice. |
| Music Therapy | Uses sound and musical expression to facilitate emotional processing. | Depression in elderly, youth, or non-verbal patients; adjunctive to other therapies. | Psychotic states, sound phobias, emotional dysregulation. | Non-verbal; accessible to less verbally engaged patients. | Strongly dependent on therapist-patient relationship. |
| Pet Therapy | Improves emotional well-being through structured animal interaction. | Depression with social withdrawal; supportive alongside other treatments. | Animal allergies, phobias, oppositional behaviors. | Stimulates empathy and relational motivation. | Not a standalone treatment; context-dependent efficacy. |
| Reminiscence Therapy | Uses autobiographical narration to strengthen identity and emotional integration. | Geriatric depression, unresolved grief; used in combination. | Severe cognitive decline, aphasia, low adherence. | Enhances self-continuity and affective integration. | Not suitable for acute depression or advanced dementia. |