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Summary table of the main psychological therapies for depression

TherapyApproachUsePrecautions and adaptationsStrengthsLimitations
Cognitive behavioral therapyIntegrates cognitive and behavioral techniques.Evidence-based option, alone or with medication according to severity and preferences.Adapt in the presence of cognitive deficits; suicide risk requires parallel safety management, not automatic exclusion.Structured and goal-oriented.Requires availability, collaboration and access to trained therapists.
Behavioral ActivationIncreases goal-consistent activities and reduces avoidance.Treatment for depression at different levels of intensity.Adapt for disability and risk; suicidal ideation is not an automatic contraindication.Pragmatic and behavior-focused.Not sufficient alone in every complex or urgent presentation.
Cognitive therapyExamines dysfunctional thoughts and beliefs.Psychological option for depression, with combination when appropriate.Techniques may be adapted; high insight is not a diagnostic requirement.A structured and studied model.Variable response; no cognitive profile guarantees efficacy.
Interpersonal therapyFocuses on grief, disputes, transitions and roles.Evidence-based treatment, including the perinatal period in relevant protocols.Adapt to communication abilities and context; isolation is not a contraindication.Brief and focused.Superiority based solely on the type of relational problem has not been demonstrated.
Brief psychodynamic therapyExplores affective and relational patterns.May be offered in depression according to preferences and clinical formulation.Acute disorganized presentations may require stabilization or adaptation, not an absolute prohibition.Attention to relationships and emotional experience.Heterogeneous comparative evidence; requires a trained therapist.
Problem-Solving TherapyWorks on practical problems and operational strategies.Structured intervention, often in primary care or at low intensity.Anhedonia or indecisiveness require adaptation, not automatic exclusion.Brief and pragmatic.Not a universal first choice or sufficient for every severe presentation.
Metacognitive therapyTargets rumination and metacognitive beliefs.A studied option, with a more limited evidence base than CBT.Adapt to cognitive abilities; there are no formal contraindications based solely on metacognitive awareness.Focused on repetitive processes.Limited data in treatment-resistant cases and over the long term.
Acceptance and Commitment TherapyPromotes psychological flexibility and values-consistent actions.Approach studied in depression; no general superiority demonstrated.Adapt language and exercises; low emotional tolerance is not a formal contraindication.Integrates acceptance and behavior.Heterogeneous specific evidence.
Mindfulness-based cognitive therapyIntegrates mindfulness practices and cognitive therapy.Main evidence is in relapse prevention; selected acute use.Adapt or defer in severe instability, psychosis or dissociation; these are not uniform prohibitions.May reduce relapse in selected populations.Requires practice and does not replace urgent management.
Music therapyUses musical experiences in a therapeutic intervention.Possible adjunct in selected settings; heterogeneous evidence.Adapt to sensory sensitivity, preferences and clinical state; psychosis is not an automatic exclusion.May facilitate engagement and expression.Studies are often small and protocols variable.
Animal-Assisted InterventionsAnimal-mediated activity or therapy in structured programs.Complementary intervention in care or rehabilitation settings.Allergies, phobias, infection risk and human and animal safety require assessment.May promote activity and relationships.Does not replace standard treatments; limited evidence.
Reminiscence TherapyUses autobiographical memories in a structured manner.Studied mainly in older people, as a psychological or psychosocial intervention.Dementia or aphasia require adaptation; traumatic memories may cause distress.May support communication and identity.Quality and effect size vary.
References
  1. National Institute for Health and Care Excellence. Depression in adults: treatment and management. NICE guideline NG222. Published 2022; last reviewed 2026.
  2. Lam RW, Kennedy SH, Adams C, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults. Can J Psychiatry. 2024;69(9):641-687. doi:10.1177/07067437241245384. PMID:38711351.
  3. Cuijpers P, Quero S, Noma H, et al. Psychotherapies for depression: a network meta-analysis covering efficacy, acceptability and long-term outcomes of all main treatment types. World Psychiatry. 2021;20(2):283-293. doi:10.1002/wps.20860.
  4. Cuijpers P, Miguel C, Harrer M, et al. Cognitive behavior therapy vs. control conditions, other psychotherapies, pharmacotherapies and combined treatment for depression: a comprehensive meta-analysis including 409 trials with 52,702 patients. World Psychiatry. 2023;22(1):105-115. doi:10.1002/wps.21069. PMID:36640411.
  5. Zhao B, Wang Q, Wang L, et al. Effect of acceptance and commitment therapy for depressive disorders: a meta-analysis. Ann Gen Psychiatry. 2023;22(1):34. PMID:37679716.
  6. Kuyken W, Warren FC, Taylor RS, et al. Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse: An Individual Patient Data Meta-analysis From Randomized Trials. JAMA Psychiatry. 2016;73(6):565-574. doi:10.1001/jamapsychiatry.2016.0076.
  7. Cohen ZD, Breunese J, Markowitz JC, et al. Comparative efficacy of interpersonal psychotherapy and antidepressant medication for adult depression: a systematic review and individual participant data meta-analysis. Psychol Med. 2024;54(14):3785-3794. doi:10.1017/S0033291724001788. PMID:39494789.
  8. Caselli I, Ielmini M, Bellini A, Zizolfi D, Callegari C. Efficacy of short-term psychodynamic psychotherapy (STPP) in depressive disorders: a systematic review and meta-analysis. J Affect Disord. 2023;325:169-176. doi:10.1016/j.jad.2022.12.161. PMID:36623570.