ST-segment elevation myocardial infarction (STEMI) is an acute cardiac condition characterized by myocardial necrosis due to prolonged ischemia, caused by the complete and persistent occlusion of a coronary artery. It is a medical emergency requiring immediate treatment to reduce mortality and prevent long-term complications.
The pathophysiology of STEMI is linked to the rupture or erosion of an unstable atherosclerotic plaque, leading to the formation of an occlusive thrombus within the coronary artery. The total obstruction of blood flow results in myocardial ischemic injury, followed by myocardial cell necrosis.
The ischemic cascade involves several phases:
The extent of myocardial damage depends on several factors, including the duration of occlusion, the presence of collateral circulation, and the individual's ischemic response.
The primary symptom of STEMI is acute chest pain, often described as intense retrosternal pressure, which may radiate to the left arm, jaw, back, or upper abdomen. The pain lasts more than 20 minutes and does not resolve with rest or nitroglycerin.
Other associated symptoms may include:
The diagnosis of STEMI is based on three fundamental criteria:
The ECG is the first diagnostic test and should be performed within 10 minutes of emergency department arrival. The primary criterion for diagnosis is a persistent ST-segment elevation in at least two contiguous leads, indicating acute coronary occlusion.
High-sensitivity troponins are the gold standard for confirming myocardial necrosis. In early stages, levels may be normal, requiring repeated testing within a few hours.
Echocardiography helps identify wall motion abnormalities, assess left ventricular ejection fraction, and detect complications such as pericardial effusion.
The goal of STEMI treatment is to restore coronary blood flow as quickly as possible to minimize myocardial necrosis.
The preferred therapeutic strategy is primary percutaneous coronary intervention (PCI) with stent placement, ideally performed within 90–120 minutes of symptom onset. If PCI is unavailable, fibrinolytic therapy is considered, but it is only effective within the first 12 hours.
Medical management includes:
The risk of post-infarction complications is high and includes:
The prognosis of STEMI depends on the timeliness of treatment. In patients undergoing early revascularization, in-hospital mortality is less than 5%, whereas in untreated cases, it can exceed 20%. Secondary prevention, focusing on cardiovascular risk factor control and adherence to medical therapy, is essential to reduce recurrence risk.